The Black and Yellow, coming off a hard-fought 3-2 victory over Borussia Monchengladbach, face challenges in maintaining their momentum.
Head coach Niko Kovac provided a grim update during Thursday's press conference. "Pascal Gross probably won't make it. Maxi is still in pain. He didn't train today.
"We won't take any medical risks," Kovac said, highlighting the club's cautious approach to player recovery.
Marcel Sabitzer's absence is also confirmed, though his return is on the horizon. "Marcel Sabitzer is making good progress. I'm confident he'll be available after the Hoffenheim match," Kovac added, offering fans some optimism.
Dortmund's official X account echoed the concerns on Friday, posting: "Injury update: Pascal Gross and Maximilian Beier doubtful for Hoffenheim. Marcel Sabitzer progressing but ruled out. #BVB #Bundesliga."
The club are focused on managing their squad depth to navigate this setback.
With Hoffenheim's attacking threat looming, Dortmund must adapt quickly. Supporters will be keen to see how their reshuffled lineup rises to the occasion in this crucial Bundesliga clash.
Xabi Alonso has emerged as the prime candidate to replace Carlo Ancelotti at Real Madrid, with the Bayer Leverkusen boss refusing to rule out a dramatic switch to the Spanish capital.
Harry Kane, Bayern Munich's striker, has opened up about his burning desire to clinch his first career trophy and overcome the sting of Champions League defeat in an interview with Absolut Fussball.
Manchester City have reportedly launched an aggressive push to sign Bayer Leverkusen's Florian Wirtz, targeting the 21-year-old as the ideal successor to their departing icon Kevin De Bruyne, according to multiple sources.
Bayer Leverkusen face a tough challenge in their Bundesliga title chase after two key players, Nordi Mukiele and Alejo Sarco, suffered muscle injuries during a training session.
